Digitalised ECG measure of p-wave duration predicts incident heart failure
نویسندگان
چکیده
Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): Uppsala University Hospital Background and purpose Early identification patients at risk congestive heart failure (HF) may potentially alter their poor prognosis. The aim was therefore to test whether the P-wave PR-interval, simple non-invasive ECG measures reflecting systolic diastolic atrial function, could predict incident HF. Methods PIVUS (Prospective Investigation Vasculature in Seniors) study including all individuals aged 70 years (1016 individuals, 50% women) used identify predictors Subjects with prevalent HF, QRS duration ≥ 130 msec or arrhythmias on baseline were excluded. Cox proportional hazard analysis relate (Pdur), amplitude (Pamp) PR interval lead V1, Adjustment performed for gender, RR-interval, beta-blocking agents, blood pressure, body mass index smoking. Results A total 107 836 (12,8%) subjects risk, developed HF during 15 follow-up. multivariate analysis, showed a strong U-shaped correlation between Pdur (p=0.0001), which significant Pdur< 60 [HR 2.75 (95% CI 1.87-4.06) 40 msec]. There no relationship Pamp. Pdur<60 improved discrimination by 3.7% when added confounders described above (p=0.048). Conclusions short P-duration, easy measure, be useful predictor developing enabling early detection treatment
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ژورنال
عنوان ژورنال: Europace
سال: 2022
ISSN: ['1099-5129', '1532-2092']
DOI: https://doi.org/10.1093/europace/euac053